Yes, as an EB-5 investor visa holder (permanent resident), you can come and go from the U.S. at will. You simply must keep your permanent residency. However, once you are outside the U.S. for more than six months, you risk abandonment of status; six months or more could be considered abandoning your permanent residency. For an absence over one year, you must apply for a reentry permit, which would allow you to remain outside the U.S. for up to two years while keeping your green card. Additionally, prolonged absences may deter you; whether you can apply for citizenship, if you want in the future.